Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 5/20 | 0.56 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31419626 | 0.82 | KDM4E (0.38) | GRNSORT1KDM4EPHGDH | |
| SCHEMBL2546897 | 0.79 | CA12 (0.42) | GRNSORT1KDM4ECA12CA1 | |
| SCHEMBL15059353 | 0.77 | GRN (0.58) | GRNSORT1KDM4ECA12CA1 | |
| SCHEMBL286931 | 0.77 | KDM4E (0.58) | GRNSORT1KDM4ECA12CA1 | |
| SCHEMBL70171 | 0.77 | KDM4E (0.58) | GRNSORT1KDM4ECA12CA1 | |
| SCHEMBL16949533 | 0.76 | KDM4E (0.53) | GRNSORT1KDM4ECA12CA1 | |
| SCHEMBL1197293 | 0.75 | KDM4E (0.56) | GRNSORT1KDM4ECA12CA1 | |
| SCHEMBL1663229 | 0.75 | GRN (0.56) | GRNSORT1KDM4ECA12CA1 | |
| SCHEMBL19253450 | 0.75 | GRN (0.56) | GRNSORT1KDM4ECA12CA1 | |
| Hydrochloric Acid SCHEMBL9680540 | 0.75 | KDM4E (0.56) | GRNSORT1KDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023205465-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |