Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | GRN | P28799 | 1/20 | 0.58 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9680540 | 0.98 | KDM4E (0.56) | KDM4EGRNSORT1SMN1; SMN2LMNA | |
| Formic Acid SCHEMBL28285920 | 0.92 | KDM4E (0.51) | KDM4EGRNSORT1SMN1; SMN2LMNA | |
| SCHEMBL27637077 | 0.84 | SMN1; SMN2 (0.48) | KDM4EGRNSORT1SMN1; SMN2LMNA | |
| SCHEMBL13982847 | 0.83 | LMNA (0.40) | KDM4EGRNSORT1SMN1; SMN2LMNA | |
| SCHEMBL334463 | 0.83 | SMN1; SMN2 (0.47) | KDM4EGRNSORT1SMN1; SMN2LMNA | |
| SCHEMBL387324 | 0.81 | SMN1; SMN2 (0.46) | KDM4EGRNSORT1SMN1; SMN2LMNA | |
| SCHEMBL2338097 | 0.81 | SMN1; SMN2 (0.46) | KDM4EGRNSORT1SMN1; SMN2LMNA | |
| SCHEMBL8571547 | 0.79 | SMN1; SMN2 (0.44) | KDM4EGRNSORT1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL5754005 | 0.79 | SMN1; SMN2 (0.44) | KDM4EGRNSORT1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL4035308 | 0.79 | SMN1; SMN2 (0.44) | KDM4EGRNSORT1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 835 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377511-B1 | AZITHROMYCIN DERIVATIVES WITH EPITHELIAL BARRIER ENHANCEMENT PROPERTIES | EPIENDO PHARMACEUTICALS EHF (IS) | 2020-05-13 | — | — | EP | claimed |
| US-10624882-B2 | Rho kinase inhibitors | AERIE PHARMACEUTICALS, INC. (US) | 2020-04-21 | — | — | US | claimed |
| US-20190070149-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2019-03-07 | — | — | US | claimed |
| CN-109081810-A | The synthetic method of 1- methyl-3-((methylamino) methyl)-1H- pyrazoles-5- nitrile | 沈阳药科大学 | 2018-12-25 | — | — | CN | claimed |
| US-20180344723-A1 | RHO KINASE INHIBITORS | ALCON INC. (CH) | 2018-12-06 | — | — | US | claimed |
| CN-108290919-A | Azithromycin derivatives having epithelial barrier enhancing properties | 艾比恩多制药有限责任公司 | 2018-07-17 | — | — | CN | claimed |
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | claimed |
| EP-2627637-B1 | N-PYRIDIN-3-YL OR N-PYRAZIN-2-YL CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2016-06-29 | — | — | EP | claimed |
| US-9328107-B2 | Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2016-05-03 | — | — | US | claimed |
| CN-103153957-B | N-pyridin-3-yl or N-pyrazin-2-yl carboxamides | HOFFMAN-LA ROCHE LTD. (CH) | 2016-01-20 | — | — | CN | claimed |
| WO-2005090331-A1 | POLYMORPHIC AND AMORPHOUS FORMS OF 2,5-DIMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID {2-FLUORO-5-[3-((E)-2-PYRIDIN-2-YL-VINYL)-1H-INDASOL-6-YLAMINO]-PHENYL}-AMIDE | PFIZER INC. (US) | 2005-09-29 | — | — | WO | claimed |
| US-6946462-B2 | N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2005-09-20 | — | — | US | claimed |
| US-20050148633-A1 | Calcium channel blockers and releasing ions for prodrugs | SYNTA PHARMACEUTICALS CORP. | 2005-07-07 | — | — | US | claimed |
| US-20050107436-A1 | phenyl and pyridyl derivatives such as 3-Fluoro-N-(2'-trifluoromethyl-biphenyl-4-yl)-isonicotinamide, used as immunosuppressants for the treatmet or prevent inflammatory and immune disorders | SYNTA PHARMACEUTICALS CORP. | 2005-05-19 | — | — | US | claimed |
| US-6869953-B2 | N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents | HOFFMAN-LA ROCHE INC. (US) | 2005-03-22 | — | — | US | claimed |
| WO-2004092177-A1 | TRIAZOLOPYRAZINES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2004-10-28 | — | — | WO | claimed |
| US-20040192744-A1 | N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents | HAAG RAINER (DE) | 2004-09-30 | — | — | US | claimed |
| US-20030139404-A1 | N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. | 2003-07-24 | — | — | US | claimed |
| EP-0658547-B1 | N-pyrazolyl carbamate derivative, agricultural/horticultural fungicide containing the same as active ingredient and production intermediate thereof | MITSUBISHI CHEM CORP (JP) | 1998-03-11 | — | — | EP | claimed |
| EP-0658547-A1 | N-pyrazolyl carbamate derivative, agricultural/horticultural fungicide containing the same as active ingredient and production intermediate thereof | MITSUBISHI CHEMICAL CORPORATION (JP) | 1995-06-21 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192744-A1 | N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents | NAT1, CYP1A1, UGT1A1 | KDM4E 2857/4885GRN 1099/4885SORT1 3800/4885 |
| US-20190070149-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | HTR5A, HTR2A, HTR1A | KDM4E 2520/4885GRN 1631/4885SORT1 618/4885 |
| US-20050148633-A1 | Calcium channel blockers and releasing ions for prodrugs | ORAI1, CACNA1C, CACNA1F | KDM4E 1800/4885GRN 3128/4885SORT1 2952/4885 |
| US-10624882-B2 | Rho kinase inhibitors | ROCK1, ROCK2, CIT | KDM4E 2089/4885GRN 4299/4885SORT1 3909/4885 |
| US-20030139404-A1 | N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents | NAT1, CYP1A1, UGT1A1 | KDM4E 2857/4885GRN 1099/4885SORT1 3800/4885 |
| US-20050107436-A1 | phenyl and pyridyl derivatives such as 3-Fluoro-N-(2'-trifluoromethyl-biphenyl-4-yl)-isonicotinamide, used as immunosuppressants for the treatmet or prevent inflammatory and immune disorders | TPMT, PTPN3, FKBP3 | KDM4E 1282/4885GRN 603/4885SORT1 1655/4885 |
| US-20180344723-A1 | RHO KINASE INHIBITORS | ROCK1, ROCK2, CIT | KDM4E 2089/4885GRN 4299/4885SORT1 3909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.