SCHEMBL1759407

SCHEMBL1759407

Brc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 11/20 1.00
CSNK2A2 P19784 8/20 1.00
CSNK2B P67870 8/20 1.00
SGK1 O00141 1/20 0.54
MEN1 O00255 1/20 0.54
NPC1 O15118 1/20 0.54
GMNN O75496 1/20 0.54
LMNA P02545 1/20 0.54
CYP3A4 P08684 1/20 0.54
MAPT P10636 1/20 0.54
NFKB1 P19838 1/20 0.54
CCNA2 P20248 1/20 0.54
CDK2 P24941 1/20 0.54
MAPK1 P28482 1/20 0.54
THPO P40225 1/20 0.54
MTOR P42345 1/20 0.54
RAB9A P51151 1/20 0.54
BLM P54132 1/20 0.54
CCNA1 P78396 1/20 0.54
PMP22 Q01453 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3867762 0.75 CSNK2A1 (0.60) CSNK2A1CSNK2A2CSNK2BSGK1MEN1
SCHEMBL1760582 0.75 CSNK2A1 (1.00) CSNK2A1CSNK2A2CSNK2BSGK1MEN1
SCHEMBL3866440 0.75 CSNK2A1 (0.60) CSNK2A1CSNK2A2CSNK2BSGK1MEN1
SCHEMBL15676524 0.73 CSNK2A1 (0.57) CSNK2A1CSNK2A2CSNK2BPIM1
SCHEMBL3868111 0.70 CSNK2A1 (1.00) CSNK2A1CSNK2A2CSNK2BSGK1MEN1
SCHEMBL1759675 0.70 CSNK2A1 (1.00) CSNK2A1CSNK2A2CSNK2BPIM1
Hydrochloric Acid SCHEMBL3866680 0.69 CSNK2A1 (0.96) CSNK2A1CSNK2A2CSNK2BSGK1MEN1
SCHEMBL1759471 0.66 PIM1 (1.00) CSNK2A1CSNK2A2CSNK2BPIM1
SCHEMBL9305150 0.65 CSNK2A1 (0.48) CSNK2A1CSNK2A2CSNK2B
SCHEMBL3873700 0.65 CSNK2A1 (0.58) CSNK2A1CSNK2A2CSNK2BSGK1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110230481-A2 DERIVATIVES OF TETRABROMOBENZIMIDAZOLE, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, A METHOD OF USING THE SAME, A METHOD FOR MODULATING OR REGULATING SERINE/THREONINE KINASES, AND SERINE/THREONINE KINASES MODULATING AGENT SELVITA S.A. (PL) 2011-09-22 US claimed
EP-2366695-A1 A compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent SELVITA S.A. (PL) 2011-09-21 EP claimed
US-20110112091-A1 DERIVATIVES OF TETRABROMOBENZIMIDAZOLE, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, A METHOF OF USING THE SAME, A METHOD FOR MODULATING OR REGULATING SERINE/THREONINE KINASES, AND SERINE/THREONINE KINASES MODULATING AGENT SELVITA SP. Z O.O. (PL) 2011-05-12 US claimed
EP-2499117-B1 A COMPOUND, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, A METHOD FOR MODULATING OR REGULATING SERINE/THREONINE KINASES AND A SERINE/THREONINE KINASES MODULATING AGENT SELVITA S A (PL) 2015-10-21 EP disclosed
US-8604217-B2 Compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent SELVITA S.A. (PL) 2013-12-10 US disclosed
EP-2499117-A1 A COMPOUND, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, A METHOD FOR MODULATING OR REGULATING SERINE/THREONINE KINASES AND A SERINE/THREONINE KINASES MODULATING AGENT SELVITA S.A. (PL) 2012-09-19 EP disclosed
US-20120184535-A1 COMPOUND, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, A METHOD FOR MODULATING OR REGULATING SERINE/THREONINE KINASES AND A SERINE/THREONINE KINASES MODULATING AGENT SELVITA S.A. (PL) 2012-07-19 US disclosed
US-20110230481-A2 DERIVATIVES OF TETRABROMOBENZIMIDAZOLE, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, A METHOD OF USING THE SAME, A METHOD FOR MODULATING OR REGULATING SERINE/THREONINE KINASES, AND SERINE/THREONINE KINASES MODULATING AGENT SELVITA S.A. (PL) 2011-09-22 US disclosed
EP-2366695-A1 A compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent SELVITA S.A. (PL) 2011-09-21 EP disclosed
WO-2011058139-A1 A COMPOUND, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, A METHOD FOR MODULATING OR REGULATING SERINE/THREONINE KINASES AND A SERINE/THREONINE KINASES MODULATING AGENT SELVITA SP. Z O. O. (PL) 2011-05-19 WO disclosed
US-20110112091-A1 DERIVATIVES OF TETRABROMOBENZIMIDAZOLE, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, A METHOF OF USING THE SAME, A METHOD FOR MODULATING OR REGULATING SERINE/THREONINE KINASES, AND SERINE/THREONINE KINASES MODULATING AGENT SELVITA SP. Z O.O. (PL) 2011-05-12 US disclosed
US-20090239921-A1 METHODS FOR TREATING NEOPLASMS WITH DERIVATIVES OF 4,5,6,7-TETRABROMOBENZIMIDAZOLE SELVITA SP. Z.O.O. (PL) 2009-09-24 US disclosed
US-7528259-B2 Derivatives of 4,5,6,7-tetrabromobenzimidazole and method of their preparation SELVITA SP. Z O. O. (PL) 2009-05-05 US disclosed
US-20070213385-A1 NEW DERIVATIVES OF 4,5,6,7-TETRABROMOBENZIMIDAZOLE AND METHOD OF THEIR PREPARATION SELVITA S.A. (PL) 2007-09-13 US disclosed
EP-1778647-A1 NEW DERIVATIVES OF 4, 5, 6, 7-TETRABROMOBENZIMIDAZOLE AND METHOD OF THEIR PREPARATION FUNDACJA ROZWOJU DIAGNOSTYKI I TERATII (PL) 2007-05-02 EP disclosed
WO-2005092866-A1 NEW DERIVATIVES OF 4, 5, 6, 7-TETRABROMOBENZIMIDAZOLE AND METHOD OF THEIR PREPARATION FUNDACJA ROZWOJU DIAGNOSTYKI I TERATII (PL) 2005-10-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110112091-A1 DERIVATIVES OF TETRABROMOBENZIMIDAZOLE, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, A METHOF OF USING THE SAME, A METHOD FOR MODULATING OR REGULATING SERINE/THREONINE KINASES, AND SERINE/THREONINE KINASES MODULATING AGENT PIM1, PIM2, PIM3 CSNK2A1 152/4885CSNK2A2 186/4885CSNK2B 185/4885
US-20120184535-A1 COMPOUND, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, A METHOD FOR MODULATING OR REGULATING SERINE/THREONINE KINASES AND A SERINE/THREONINE KINASES MODULATING AGENT ITK, HASPIN, HCK CSNK2A1 349/4885CSNK2A2 418/4885CSNK2B 321/4885
US-20070213385-A1 NEW DERIVATIVES OF 4,5,6,7-TETRABROMOBENZIMIDAZOLE AND METHOD OF THEIR PREPARATION CYP3A4, IL4I1, CYP4B1 CSNK2A1 1059/4885CSNK2A2 1023/4885CSNK2B 840/4885
US-20090239921-A1 METHODS FOR TREATING NEOPLASMS WITH DERIVATIVES OF 4,5,6,7-TETRABROMOBENZIMIDAZOLE CSNK2A2, CSNK2A1, CSNK2B CSNK2A1 2/4885CSNK2A2 1/4885CSNK2B 3/4885
US-20110230481-A2 DERIVATIVES OF TETRABROMOBENZIMIDAZOLE, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, A METHOD OF USING THE SAME, A METHOD FOR MODULATING OR REGULATING SERINE/THREONINE KINASES, AND SERINE/THREONINE KINASES MODULATING AGENT PIM1, PIM2, PIM3 CSNK2A1 46/4885CSNK2A2 58/4885CSNK2B 40/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.