Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19253856 | 1.00 | MEN1 (0.40) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL19253857 | 1.00 | MEN1 (0.40) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL19253860 | 0.92 | MEN1 (0.39) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL19253859 | 0.92 | MEN1 (0.39) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL19277937 | 0.90 | PTPN11 (0.45) | MEN1LMNAKMT2APTPN11CA2 | |
| SCHEMBL19277934 | 0.83 | PTPN11 (0.44) | MEN1LMNAKMT2APTPN11CA2 | |
| SCHEMBL19253846 | 0.82 | MEN1 (0.45) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL19253847 | 0.82 | MEN1 (0.45) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL17822759 | 0.82 | MEN1 (0.42) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL17822758 | 0.82 | MEN1 (0.42) | MEN1LMNAKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191490-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | Medimmune Limited (GB) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016038383-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LIMITED (GB) | 2016-03-17 | — | — | WO | disclosed |