Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19253860 | 1.00 | MEN1 (0.39) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL19253857 | 0.92 | MEN1 (0.40) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL17594102 | 0.92 | MEN1 (0.40) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL19253856 | 0.92 | MEN1 (0.40) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL19277934 | 0.90 | PTPN11 (0.44) | MEN1LMNAKMT2APTPN11CA2 | |
| SCHEMBL19277937 | 0.83 | PTPN11 (0.45) | MEN1LMNAKMT2APTPN11CA2 | |
| SCHEMBL19253846 | 0.82 | MEN1 (0.45) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL19253847 | 0.82 | MEN1 (0.45) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL17592844 | 0.80 | MEN1 (0.44) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL17592842 | 0.80 | MEN1 (0.44) | MEN1LMNAKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10420777-B2 | Pyrrolobenzodiazepines and conjugates thereof | MEDIMMUNE LIMITED (GB) | 2019-09-24 | — | — | US | disclosed |
| EP-3191490-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LTD (GB) | 2019-08-07 | — | — | EP | disclosed |
| US-20170239365-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LIMITED (GB) | 2017-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10420777-B2 | Pyrrolobenzodiazepines and conjugates thereof | CD79B, BOD1L1, GABRA1 | MEN1 1480/4885LMNA 1707/4885KMT2A 2541/4885 |
| US-20170239365-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | CD79B, BOD1L1, GABRA1 | MEN1 1480/4885LMNA 1707/4885KMT2A 2541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.