Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 16/20 | 0.47 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17595703 | 1.00 | P2RX7 (0.47) | P2RX7TACR3MLNRGAATSHR | |
| SCHEMBL17595691 | 0.84 | P2RX7 (0.34) | P2RX7 | |
| SCHEMBL17595687 | 0.84 | P2RX7 (0.34) | P2RX7 | |
| SCHEMBL17596250 | 0.83 | P2RX7 (0.43) | P2RX7GAATSHR | |
| SCHEMBL17596252 | 0.83 | P2RX7 (0.43) | P2RX7GAATSHR | |
| SCHEMBL17595700 | 0.81 | GAA (0.51) | P2RX7GAATSHR | |
| SCHEMBL17595699 | 0.81 | GAA (0.51) | P2RX7GAATSHR | |
| SCHEMBL16093930 | 0.77 | P2RX7 (0.50) | P2RX7TACR3GAATSHR | |
| SCHEMBL16093928 | 0.77 | P2RX7 (0.50) | P2RX7TACR3GAATSHR | |
| SCHEMBL17596657 | 0.77 | P2RX7 (0.48) | P2RX7TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191488-A1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | Janssen Pharmaceutica, N.V. (BE) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016039983-A1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-17 | — | — | WO | disclosed |