Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17594159 | 0.85 | CYP3A4 (0.42) | PIM1PIM3PIM2CYP3A4FGFR1 | |
| SCHEMBL29931793 | 0.85 | CYP3A4 (0.42) | PIM1PIM3PIM2CYP3A4FGFR1 | |
| SCHEMBL17596972 | 0.84 | PIM1 (0.49) | PIM1PIM3PIM2MAPK1CYP3A4 | |
| SCHEMBL17592147 | 0.82 | PIM1 (0.47) | PIM1PIM3PIM2MAPK1CYP3A4 | |
| SCHEMBL17593558 | 0.81 | CYP3A4 (0.38) | PIM1PIM3PIM2CYP3A4FGFR1 | |
| SCHEMBL17592363 | 0.81 | PIM1 (0.46) | PIM1PIM3PIM2MAPK1CYP3A4 | |
| SCHEMBL17598043 | 0.81 | PIM1 (0.48) | PIM1PIM3PIM2MAPK1CYP3A4 | |
| SCHEMBL17596792 | 0.80 | CYP3A4 (0.38) | PIM1PIM3PIM2CYP3A4CYP3A5 | |
| SCHEMBL17592176 | 0.79 | PIM1 (0.45) | PIM1PIM3PIM2MAPK1CYP3A4 | |
| SCHEMBL17591682 | 0.77 | CYP3A4 (0.47) | CYP3A4CYP3A5LMNACYP1A2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040181-A1 | 3-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF | SAMUMED, LLC (US) | 2016-03-17 | — | — | WO | claimed |
| WO-2016040188-A1 | 3-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF | SAMUMED, LLC (US) | 2016-03-17 | — | — | WO | claimed |