Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.36 |
| ▸ | WNT3A | P56704 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.34 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17592815 | 0.92 | PIM1 (0.45) | PIM1PIM2PIM3CTNNB1WNT3A | |
| SCHEMBL17593554 | 0.84 | NPC1 (0.44) | PIM1PIM2PIM3FGFR1CTNNB1 | |
| SCHEMBL17596972 | 0.83 | PIM1 (0.49) | PIM1PIM2PIM3MAPK1FGFR1 | |
| SCHEMBL17592147 | 0.81 | PIM1 (0.47) | PIM1PIM2PIM3MAPK1FGFR1 | |
| SCHEMBL18454467 | 0.81 | NAMPT (0.39) | PIM1PIM2PIM3FGFR1CTNNB1 | |
| SCHEMBL17596381 | 0.81 | PIM1 (0.46) | PIM1PIM2PIM3MAPK1FGFR1 | |
| SCHEMBL17592363 | 0.81 | PIM1 (0.46) | PIM1PIM2PIM3MAPK1FGFR1 | |
| SCHEMBL17591695 | 0.80 | KCNN4 (0.39) | PIM1PIM2PIM3KCNN4CYP3A4 | |
| SCHEMBL17598040 | 0.79 | KCNN4 (0.35) | KCNN4CYP3A4CYP3A5KCNA5 | |
| SCHEMBL17592176 | 0.79 | PIM1 (0.45) | PIM1PIM2PIM3MAPK1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040188-A1 | 3-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF | SAMUMED, LLC (US) | 2016-03-17 | — | — | WO | claimed |