Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 20/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17596453 | 1.00 | P2RX7 (0.83) | P2RX7 | |
| SCHEMBL20099698 | 0.94 | P2RX7 (0.85) | P2RX7 | |
| SCHEMBL17596267 | 0.92 | P2RX7 (0.82) | P2RX7 | |
| SCHEMBL17596269 | 0.92 | P2RX7 (0.82) | P2RX7 | |
| SCHEMBL17596622 | 0.91 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL20099706 | 0.91 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL29794054 | 0.91 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL17596620 | 0.91 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL17595605 | 0.89 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL20099705 | 0.89 | P2RX7 (1.00) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191488-A1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | Janssen Pharmaceutica, N.V. (BE) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016039983-A1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-17 | — | — | WO | disclosed |