Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Crotonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.39 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Crotonic Acid SCHEMBL9735696 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3FFAR3 | |
| Crotonic Acid SCHEMBL28833763 | 0.97 | TSHR (0.47) | TSHRTP53EGLN1EGLN3FFAR3 | |
| Crotonic Acid SCHEMBL1428157 | 0.93 | TSHR (0.57) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Crotonic Acid SCHEMBL560763 | 0.93 | TSHR (0.57) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Crotonic Acid SCHEMBL22033 | 0.93 | — | — | |
| Crotonic Acid SCHEMBL1427547 | 0.93 | TSHR (0.57) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Crotonic Acid SCHEMBL22034 | 0.93 | — | — | |
| Crotonic Acid SCHEMBL28429 | 0.93 | — | — | |
| Crotonic Acid SCHEMBL167626 | 0.93 | TSHR (0.57) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Crotonic Acid SCHEMBL1080122 | 0.93 | TSHR (0.57) | TSHRTP53EGLN1EGLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017359-B2 | HAIR-SETTING AGENT WITH AMPHOTERIC AND ACIDIC POLYMERS | WELLA AG (DE) | 2008-07-09 | — | — | EP | claimed |
| EP-1223949-A1 | EXTENDED RELEASE FORMULATIONS OF ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 2002-07-24 | — | — | EP | claimed |
| WO-2001026663-A1 | EXTENDED RELEASE FORMULATIONS OF ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 2001-04-19 | — | — | WO | claimed |
| EP-0404727-B1 | Polymer base blend compositions containing destructurized starch | WARNER LAMBERT CO (US) | 1994-06-01 | — | — | EP | claimed |
| US-5156709-A | Optically detectable stripe which becomes transparent on application of heat or pressure | XEROX CORPORATION (US) | 1992-10-20 | — | — | US | claimed |
| EP-0404727-A2 | Polymer base blend compositions containing destructurized starch | WARNER-LAMBERT COMPANY (US) | 1990-12-27 | — | — | EP | claimed |
| JP-4342757-A | — | — | None | — | — | JP | disclosed |
| EP-3817710-A1 | MULTICOMPONENT SILICONE COMPOSITION | HFC Prestige International Holding Switzerland S.a.r.l. (CH) | 2021-05-12 | — | — | EP | disclosed |
| EP-3817825-A1 | MULTICOMPONENT PUR COMPOSITION | HFC Prestige International Holding Switzerland S.a.r.l. (CH) | 2021-05-12 | — | — | EP | disclosed |
| EP-3405263-B1 | NOVEL PROBIOTIC BACTERIAL STRAIN OF LACTOBACILLUS PLANTARUM AND COMPOSITIONS AND USES THEREOF IN THE TREATMENT OF INFLAMMATION | PROBI AB (SE) | 2021-03-10 | — | — | EP | disclosed |
| EP-3787753-A1 | MULTICOMPONENT COMPOSITION | HFC Prestige International Holding Switzerland S.a.r.l. (CH) | 2021-03-10 | — | — | EP | disclosed |
| EP-3405205-B1 | PROBIOTICS FOR USE AS ANTI-INFLAMMATORY AGENTS IN THE ORAL CAVITY | SYMRISE AG (DE) | 2020-07-15 | — | — | EP | disclosed |
| EP-3607938-A2 | PHARMACEUTICAL COMPOSITION | Sovic Brkicic Ljiljana (HR) | 2020-02-12 | — | — | EP | disclosed |
| US-4394479-A | CARBOXYLIC ACID MONOMER | MONSANTO COMPANY (US) | 1983-07-19 | — | — | US | disclosed |
| US-4248591-A | HAIR DYES | L'OREAL (FR) | 1981-02-03 | — | — | US | disclosed |
| US-4221729-A | HAIR DYES | L'OREAL (FR) | 1980-09-09 | — | — | US | disclosed |
| US-4150115-A | HAIR AND SKIN CONDITIONERS | L'OREAL (FR) | 1979-04-17 | — | — | US | disclosed |
| US-4093806-A | HAIR DYES | L'OREAL (FR) | 1978-06-06 | — | — | US | disclosed |
| US-4046786-A | HAIR DYES | L'OREAL (FR) | 1977-09-06 | — | — | US | disclosed |
| US-4012302-A | Photocurable compositions containing s-aryl arylcarbothioic acid esters as photoinitiators | EASTMAN KODAK COMPANY (US) | 1977-03-15 | — | — | US | disclosed |