Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.30 |
| ▸ | TNKS | O95271 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
| ▸ | MPL | P40238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17597455 | 0.99 | TLR8 (0.33) | TLR7TLR8TLR9 | |
| SCHEMBL14741079 | 0.84 | NOTUM (0.41) | TLR7TLR8TNKSPARP1TNKS2 | |
| SCHEMBL14745370 | 0.83 | NOTUM (0.44) | — | |
| SCHEMBL14741280 | 0.82 | PARP1 (0.39) | TLR7TLR8TLR9TNKSPARP1 | |
| SCHEMBL17597633 | 0.81 | JAK2 (0.36) | TLR7TLR8 | |
| SCHEMBL17597124 | 0.81 | PDE3B (0.42) | PARP1 | |
| SCHEMBL17597194 | 0.79 | MEN1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL17597730 | 0.78 | MEN1 (0.33) | — | |
| SCHEMBL14744809 | 0.78 | ALDH1A1 (0.36) | TLR7TLR8TLR9PARP1MPL | |
| SCHEMBL14744987 | 0.77 | ALDH1A1 (0.37) | TLR7TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016039939-A1 | BICYCLIC AND TRICYCLIC SUBSTITUTED 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | claimed |
| WO-2016039939-A1 | BICYCLIC AND TRICYCLIC SUBSTITUTED 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |