Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760404 | 0.86 | NPC1 (0.45) | SMN1; SMN2 | |
| SCHEMBL1832205 | 0.82 | TAAR1 (0.60) | TAAR1 | |
| SCHEMBL1760021 | 0.78 | TAAR1 (0.64) | TAAR1 | |
| SCHEMBL1760023 | 0.78 | TAAR1 (0.64) | TAAR1 | |
| SCHEMBL1759920 | 0.78 | TAAR1 (0.53) | SMN1; SMN2TAAR1 | |
| SCHEMBL1774031 | 0.78 | TAAR1 (0.53) | SMN1; SMN2TAAR1 | |
| SCHEMBL1759746 | 0.76 | TAAR1 (0.53) | TAAR1 | |
| SCHEMBL1759747 | 0.76 | TAAR1 (0.53) | TAAR1 | |
| SCHEMBL502865 | 0.74 | — | — | |
| SCHEMBL1760187 | 0.74 | TAAR1 (0.53) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499121-A1 | OXAZOLINE DERIVATIVES FOR TREATMENT OF CNS DISORDERS. | F. Hoffmann-La Roche AG (CH) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011057973-A1 | OXAZOLINE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |