Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1759924 | 0.86 | MEN1 (0.51) | SMN1; SMN2 | |
| SCHEMBL1759688 | 0.81 | TAAR1 (0.60) | — | |
| SCHEMBL1759691 | 0.81 | TAAR1 (0.60) | — | |
| SCHEMBL1760264 | 0.79 | TAAR1 (0.62) | — | |
| SCHEMBL1760263 | 0.79 | TAAR1 (0.62) | — | |
| SCHEMBL1832205 | 0.79 | TAAR1 (0.60) | — | |
| SCHEMBL1760229 | 0.75 | TAAR1 (0.51) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1760224 | 0.75 | TAAR1 (0.51) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20784606 | 0.71 | HSD17B10 (0.56) | NPC1RAB9ASMN1; SMN2AOC3 | |
| SCHEMBL1759864 | 0.69 | TAAR1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499121-A1 | OXAZOLINE DERIVATIVES FOR TREATMENT OF CNS DISORDERS. | F. Hoffmann-La Roche AG (CH) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011057973-A1 | OXAZOLINE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |