Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | PPARA | Q07869 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | CTRC | Q99895 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 6/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599529 | 0.92 | KDM4E (0.41) | PPARGPPARAKDM4EKMT2AMEN1 | |
| SCHEMBL17599536 | 0.79 | KDM4E (0.47) | KDM4EKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL17599543 | 0.78 | KDM4E (0.43) | PPARGPPARAKDM4EKMT2AMEN1 | |
| SCHEMBL17614087 | 0.75 | PPARG (0.57) | PPARGPPARAKDM4EKMT2ACTRC | |
| SCHEMBL17599531 | 0.73 | KDM4E (0.44) | KDM4EKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL17599534 | 0.73 | KDM4E (0.44) | KDM4EKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL17599533 | 0.73 | KDM4E (0.44) | KDM4EKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL17614126 | 0.72 | KDM4E (0.41) | KDM4EKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL28617984 | 0.72 | PPARA (0.79) | PPARGPPARACTRCPTGESALOX5 | |
| SCHEMBL17599535 | 0.71 | KDM4E (0.53) | KDM4EKMT2AMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | claimed |
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |