Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 2/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | CDC25C | P30307 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599523 | 0.92 | PPARG (0.45) | KDM4EKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL17599543 | 0.77 | KDM4E (0.43) | KDM4EKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL17599528 | 0.77 | ALDH2 (0.44) | KDM4EKMT2AALDH1A1HSD17B10CDC25B | |
| SCHEMBL17599536 | 0.76 | KDM4E (0.47) | KDM4EKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL27709801 | 0.74 | PPARG (0.59) | ALDH2LMNAPPARGPPARAGAA | |
| SCHEMBL10727383 | 0.74 | PPARG (0.59) | ALDH2LMNAPPARGPPARAGAA | |
| SCHEMBL17599537 | 0.73 | L3MBTL1 (0.43) | KDM4EKMT2AALDH1A1HPGDCRHBP | |
| SCHEMBL17614126 | 0.71 | KDM4E (0.41) | KDM4EKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL17599533 | 0.71 | KDM4E (0.44) | KDM4EKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL17599531 | 0.71 | KDM4E (0.44) | KDM4EKMT2AALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |