Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 5/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PTGFR | P43088 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.40 |
| ▸ | IDH1 | O75874 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599525 | 0.70 | KMT2A (0.51) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL28858320 | 0.68 | ACP3 (0.63) | MEN1KMT2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL17599552 | 0.67 | KDM4E (0.47) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL17599372 | 0.66 | ALDH1A1 (0.62) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL3674481 | 0.66 | MEN1 (0.61) | MEN1KMT2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL17599329 | 0.65 | KMT2A (0.55) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL17599363 | 0.65 | MEN1 (0.53) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL6368429 | 0.64 | CHRM2 (0.54) | MEN1KMT2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6368425 | 0.64 | CHRM2 (0.54) | MEN1KMT2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6368432 | 0.64 | CHRM2 (0.54) | MEN1KMT2AALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |