Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591436 | 0.88 | PDE4D (0.48) | PRF1LMNAKDM4ECYP3A4PDE4D | |
| SCHEMBL2596115 | 0.88 | CYP3A4 (0.51) | PRF1LMNAKDM4ECYP3A4PDE4D | |
| SCHEMBL7716197 | 0.87 | PRF1 (0.46) | PRF1LMNAKDM4ECYP3A4PDE4D | |
| SCHEMBL2593958 | 0.86 | PDE4D (0.47) | PRF1LMNAKDM4ECYP3A4PDE4D | |
| SCHEMBL2585895 | 0.86 | PDE4D (0.48) | PRF1LMNAKDM4ECYP3A4PDE4D | |
| SCHEMBL2589787 | 0.86 | PRF1 (0.48) | PRF1LMNAKDM4ECYP3A4PDE4D | |
| SCHEMBL17599585 | 0.85 | PDE4D (0.48) | PRF1LMNAKDM4ECYP3A4PDE4D | |
| SCHEMBL2584360 | 0.85 | PRF1 (0.48) | PRF1LMNAKDM4ECYP3A4PDE4D | |
| SCHEMBL2592360 | 0.85 | PRF1 (0.51) | PRF1LMNAKDM4ECYP3A4PDE4D | |
| SCHEMBL7713010 | 0.84 | PDE4D (0.50) | PRF1LMNAKDM4ECYP3A4PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | disclosed |