Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.53 |
| ▸ | PDE2A | O00408 | 7/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599734 | 1.00 | METAP2 (0.53) | METAP2PDE2APDE3ACHRNB2CHRNA4 | |
| SCHEMBL1333134 | 0.88 | PDE2A (0.59) | METAP2PDE2APDE3ACHRNB2CHRNA4 | |
| SCHEMBL1333130 | 0.88 | PDE2A (0.59) | METAP2PDE2APDE3ACHRNB2CHRNA4 | |
| SCHEMBL1331935 | 0.87 | METAP2 (0.55) | METAP2PDE2APDE3ACHRNB2CHRNA4 | |
| SCHEMBL1333550 | 0.87 | METAP2 (0.55) | METAP2PDE2APDE3ACHRNB2CHRNA4 | |
| SCHEMBL1333552 | 0.87 | METAP2 (0.55) | METAP2PDE2APDE3ACHRNB2CHRNA4 | |
| SCHEMBL1331485 | 0.87 | METAP2 (0.55) | METAP2PDE2APDE3ACHRNB2CHRNA4 | |
| SCHEMBL1331931 | 0.87 | METAP2 (0.55) | METAP2PDE2APDE3ACHRNB2CHRNA4 | |
| SCHEMBL1331482 | 0.87 | METAP2 (0.55) | METAP2PDE2APDE3ACHRNB2CHRNA4 | |
| SCHEMBL17599723 | 0.87 | METAP2 (0.60) | METAP2PDE2APDE3ACHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379558-B1 | NOVEL HETEROCYCLIC COMPOUNDS FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2016-03-23 | — | — | EP | claimed |