Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 10/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22199092 | 0.84 | IDH1 (0.51) | IDH1FGFR1FGFR2FGFR3MAP2K1 | |
| SCHEMBL17604498 | 0.83 | IDH1 (0.53) | IDH1FGFR1FGFR2FGFR3 | |
| SCHEMBL21549749 | 0.81 | IDH1 (0.60) | IDH1TRPV1 | |
| SCHEMBL22199087 | 0.80 | IDH1 (0.47) | IDH1FGFR1FGFR2FGFR3MAP2K1 | |
| SCHEMBL18744770 | 0.80 | IDH1 (0.50) | IDH1FGFR1FGFR2FGFR3MAP2K1 | |
| SCHEMBL22199102 | 0.80 | IDH1 (0.47) | IDH1FGFR1FGFR2FGFR3MAP2K1 | |
| SCHEMBL17601152 | 0.79 | IDH1 (0.58) | IDH1FGFR1FGFR2FGFR3TRPV1 | |
| SCHEMBL20003991 | 0.79 | IDH1 (0.47) | IDH1FGFR1FGFR2FGFR3MAP2K1 | |
| SCHEMBL30065246 | 0.79 | IDH1 (0.58) | IDH1FGFR1FGFR2FGFR3TRPV1 | |
| SCHEMBL17601153 | 0.79 | IDH1 (0.58) | IDH1FGFR1FGFR2FGFR3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016171756-A1 | QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-27 | — | — | WO | claimed |
| EP-3194375-A1 | PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016171756-A1 | QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-27 | — | — | WO | disclosed |
| WO-2016044782-A1 | PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-03-24 | — | — | WO | disclosed |