Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 9/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 6/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22199092 | 0.82 | IDH1 (0.51) | IDH1FGFR1FGFR2FGFR3MAP2K1 | |
| SCHEMBL17604498 | 0.81 | IDH1 (0.53) | IDH1FGFR1FGFR2FGFR3 | |
| SCHEMBL18744770 | 0.80 | IDH1 (0.50) | IDH1FGFR1FGFR2FGFR3MAP2K1 | |
| SCHEMBL17601152 | 0.80 | IDH1 (0.58) | IDH1FGFR1FGFR2FGFR3TRPV1 | |
| SCHEMBL17601153 | 0.80 | IDH1 (0.58) | IDH1FGFR1FGFR2FGFR3TRPV1 | |
| SCHEMBL30065246 | 0.80 | IDH1 (0.58) | IDH1FGFR1FGFR2FGFR3TRPV1 | |
| SCHEMBL21549749 | 0.79 | IDH1 (0.60) | IDH1TRPV1 | |
| SCHEMBL17604497 | 0.79 | IDH1 (0.49) | IDH1FGFR1FGFR2FGFR3MAP2K1 | |
| Hydrochloric Acid SCHEMBL17601586 | 0.79 | IDH1 (0.57) | IDH1FGFR1FGFR2FGFR3TRPV1 | |
| Hydrochloric Acid SCHEMBL17601587 | 0.79 | IDH1 (0.57) | IDH1FGFR1FGFR2FGFR3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230125739-A1 | PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | US | disclosed |
| US-10253015-B2 | Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors | FORMA TM2, INC. (US) | 2019-04-09 | — | — | US | disclosed |
| US-20180086733-A1 | PYRIDINYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10253015-B2 | Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors | IDH1, IDH3A, IDH3B | IDH1 1/4885FGFR1 565/4885FGFR2 1170/4885 |
| US-20230125739-A1 | PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | IDH1, IDH3A, IDH2 | IDH1 1/4885FGFR1 408/4885FGFR2 935/4885 |
| US-20180086733-A1 | PYRIDINYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | IDH1, IDH3A, IDH3B | IDH1 1/4885FGFR1 565/4885FGFR2 1170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.