Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GYS1 | P13807 | 19/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1759884 | 0.86 | GYS1 (0.50) | GYS1 | |
| SCHEMBL1759672 | 0.84 | GYS1 (0.53) | GYS1 | |
| SCHEMBL1760075 | 0.82 | GYS1 (0.56) | GYS1 | |
| SCHEMBL1759586 | 0.82 | GYS1 (0.49) | GYS1 | |
| SCHEMBL1759588 | 0.79 | GYS1 (0.49) | GYS1 | |
| SCHEMBL1759662 | 0.78 | GYS1 (0.48) | GYS1 | |
| SCHEMBL1759957 | 0.75 | GYS1 (0.48) | GYS1 | |
| SCHEMBL1760356 | 0.74 | GYS1 (0.59) | GYS1 | |
| SCHEMBL1759590 | 0.73 | NR4A2 (0.47) | — | |
| SCHEMBL1760107 | 0.73 | GYS1 (0.55) | GYS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011057959-A1 | INDOLE AND INDAZOLE DERIVATIVES AS GLYCOGEN SYNTHASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |