Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.55 |
| ▸ | CLK2 | P49760 | 5/20 | 0.55 |
| ▸ | CLK3 | P49761 | 4/20 | 0.55 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | NAMPT | P43490 | 11/20 | 0.52 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17607239 | 0.86 | TMIGD3 (0.46) | MAPK7DYRK1ACLK2CLK3NAMPT | |
| SCHEMBL4506952 | 0.81 | GSK3B (0.50) | MAPK7DYRK1AGSK3BNAMPT | |
| SCHEMBL20265901 | 0.76 | MAPK7 (1.00) | MAPK7 | |
| SCHEMBL22235838 | 0.72 | DYRK1A (0.59) | MAPK7DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22236189 | 0.71 | DYRK1A (0.59) | MAPK7DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22235982 | 0.71 | DYRK1A (0.75) | MAPK7DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22235957 | 0.71 | DYRK1A (0.59) | MAPK7DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL17096486 | 0.71 | DYRK1A (0.77) | DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL22236116 | 0.71 | DYRK1A (0.64) | MAPK7DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL23449166 | 0.71 | EHMT2 (0.56) | MAPK7DYRK1ACLK2CLK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194390-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | Cancer Research Technology Ltd (GB) | 2017-07-26 | — | — | EP | claimed |
| WO-2016042341-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-03-24 | — | — | WO | claimed |