Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 8/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PAICS | P22234 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17607252 | 0.86 | MAPK7 (0.60) | MAPK7TDO2NAMPTCLK2CLK3 | |
| SCHEMBL16605358 | 0.80 | S1PR1 (0.55) | MAPK7TDO2NAMPTPAICSTMEM97 | |
| SCHEMBL17607243 | 0.76 | MAPK7 (0.47) | TMIGD3ADORA1MAPK7KDM1ARCOR1 | |
| SCHEMBL3696334 | 0.75 | NAMPT (0.74) | NAMPT | |
| SCHEMBL3696332 | 0.75 | NAMPT (0.52) | TDO2NAMPTPAICSTMEM97SIGMAR1 | |
| SCHEMBL20265752 | 0.74 | MAPK7 (0.80) | MAPK7 | |
| SCHEMBL13993605 | 0.74 | CDK14 (0.47) | MAPK7PAICSTMEM97SIGMAR1CLK2 | |
| SCHEMBL16605370 | 0.73 | PAICS (0.50) | PAICS | |
| SCHEMBL17607174 | 0.71 | MAPK7 (0.58) | TMIGD3ADORA1MAPK7KDM1ARCOR1 | |
| SCHEMBL4061052 | 0.70 | NAMPT (0.49) | MAPK7NAMPTCLK2CLK3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194390-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | Cancer Research Technology Ltd (GB) | 2017-07-26 | — | — | EP | claimed |
| WO-2016042341-A1 | PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHBITION OF ERK5 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-03-24 | — | — | WO | claimed |