Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.43 |
| ▸ | ATR | Q13535 | 3/20 | 0.43 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19367479 | 0.84 | CRHBP (0.55) | LRRK2ATRATRIPCRHBPCRHR2 | |
| SCHEMBL15938813 | 0.78 | CYP2C19 (0.56) | CYP2C19CRHBPCRHR2MEN1POLB | |
| SCHEMBL17608163 | 0.74 | AURKA (0.38) | LRRK2PDPK1POLBALDH1A1HPGD | |
| SCHEMBL28798344 | 0.74 | CRHBP (0.65) | CYP2C19CRHBPCRHR2PDPK1MEN1 | |
| SCHEMBL22488129 | 0.73 | RAF1 (0.58) | CYP2C19CRHBPCRHR2ALDH1A1GAA | |
| SCHEMBL13815773 | 0.73 | CNR2 (0.53) | ATR | |
| SCHEMBL922909 | 0.71 | KMT2A (0.49) | CYP2C19LRRK2CRHBPCRHR2PDPK1 | |
| Hydrochloric Acid SCHEMBL925122 | 0.70 | KMT2A (0.47) | CYP2C19LRRK2CRHBPCRHR2PDPK1 | |
| SCHEMBL17608158 | 0.69 | PIK3C3 (0.47) | MEN1POLBKMT2APIK3CAALDH1A1 | |
| SCHEMBL17608780 | 0.68 | IGF1R (0.40) | LRRK2ATRATRIPPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10189810-B2 | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors | VERSEON CORPORATION (US) | 2019-01-29 | — | — | US | disclosed |
| US-10189810-B2 | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors | VERSEON CORPORATION (US) | 2019-01-29 | — | — | US | disclosed |
| US-20170267656-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2017-09-21 | — | — | US | disclosed |
| US-20170267656-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2017-09-21 | — | — | US | disclosed |
| EP-3194369-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | Verseon Corporation (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044662-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON CORPORATION (US) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016044662-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON CORPORATION (US) | 2016-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267656-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | SERPINE1, PRSS1, SPINT2 | CYP2C19 514/4885LRRK2 411/4885ATR 880/4885 |
| US-10189810-B2 | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors | SERPINE1, PRSS1, SPINT2 | CYP2C19 514/4885LRRK2 411/4885ATR 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.