Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735161 | 0.91 | KDM4E (0.63) | KDM4EOPRK1ESR1ESR2ADRB2 | |
| SCHEMBL17609368 | 0.77 | ESR1 (0.60) | KDM4EESR1ESR2SLC6A2LMNA | |
| SCHEMBL926427 | 0.73 | APP (0.52) | KDM4EESR1ESR2SLC6A2LMNA | |
| SCHEMBL17609119 | 0.72 | ESR1 (0.45) | KDM4EESR1ESR2SLC6A2LMNA | |
| SCHEMBL8411707 | 0.72 | SLC6A4 (0.60) | OPRK1ESR1ESR2SLC6A2SLC6A4 | |
| SCHEMBL555308 | 0.72 | KDM4E (0.57) | KDM4EOPRK1SLC6A2SIGMAR1ADRA2B | |
| SCHEMBL104626 | 0.72 | ESR1 (0.59) | KDM4EOPRK1ESR1ESR2ADRB2 | |
| SCHEMBL27502153 | 0.71 | ABAT (0.67) | KDM4EESR1ESR2SLC6A2ADRA2A | |
| SCHEMBL13698052 | 0.70 | ESR1 (0.56) | KDM4EOPRK1ESR1ESR2ADRB2 | |
| SCHEMBL13698055 | 0.70 | ESR1 (0.56) | KDM4EOPRK1ESR1ESR2ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193601-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044429-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |