Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | ESR1 | P03372 | 3/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17609151 | 0.91 | KDM4E (0.55) | KDM4EESR1ESR2OPRK1ADRB2 | |
| SCHEMBL555308 | 0.79 | KDM4E (0.57) | KDM4EOPRK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8411707 | 0.79 | SLC6A4 (0.60) | ESR1ESR2OPRK1SLC6A2SLC6A4 | |
| SCHEMBL104626 | 0.79 | ESR1 (0.59) | KDM4EESR1ESR2OPRK1ADRB2 | |
| SCHEMBL105870 | 0.77 | ESR1 (0.56) | KDM4EESR1ESR2OPRK1ADRB2 | |
| SCHEMBL13698052 | 0.77 | ESR1 (0.56) | KDM4EESR1ESR2OPRK1ADRB2 | |
| SCHEMBL13698055 | 0.77 | ESR1 (0.56) | KDM4EESR1ESR2OPRK1ADRB2 | |
| SCHEMBL17625064 | 0.76 | LOXL2 (0.43) | KDM4ELMNAMAPK1CYP3A4CYP1A2 | |
| Hydrochloric Acid SCHEMBL9734626 | 0.76 | KCNH2 (0.50) | KDM4ESLC6A2ADRA2ALMNASLC6A4 | |
| Hydrochloric Acid SCHEMBL9734986 | 0.76 | HTT (0.54) | KDM4ESLC6A4MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135955-A | Anticoagulants or antifungal activity | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0339878-A2 | Propanamine derivatives | ELI LILLY AND COMPANY (US) | 1989-11-02 | — | — | EP | disclosed |