Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 19/20 | 0.53 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.51 |
| ▸ | KDM5A | P29375 | 2/20 | 0.51 |
| ▸ | KDM6B | O15054 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17619722 | 0.90 | KDM4C (0.44) | KDM4CKDM5BKDM5AKDM4EPDE4B | |
| SCHEMBL17619632 | 0.89 | KDM4C (0.49) | KDM4CKDM5BKDM5AKDM6BKDM4E | |
| SCHEMBL17610425 | 0.86 | KDM4C (0.62) | KDM4CKDM5BKDM5AKDM4D | |
| SCHEMBL17619630 | 0.85 | KDM4C (0.60) | KDM4CKDM5BKDM5AKDM6BKDM4E | |
| SCHEMBL17610424 | 0.82 | KDM4C (0.51) | KDM4CKDM5BKDM5AKDM6BKDM4E | |
| SCHEMBL17610429 | 0.82 | GRM5 (0.56) | KDM4CKDM5BKDM5AKDM4E | |
| SCHEMBL17619512 | 0.81 | KDM4C (0.44) | KDM4CKDM5BKDM5A | |
| SCHEMBL17619646 | 0.81 | GRM5 (0.53) | KDM4CKDM5BKDM5AKDM4E | |
| SCHEMBL17619669 | 0.79 | KDM4C (0.54) | KDM4CKDM5BKDM5A | |
| SCHEMBL17610459 | 0.79 | KDM4C (0.55) | KDM4CKDM5BKDM5AKDM6BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170291890-A1 | HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | Epizyme, Inc. | 2017-10-12 | — | — | US | disclosed |
| US-20170291890-A1 | HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | Epizyme, Inc. | 2017-10-12 | — | — | US | disclosed |
| US-20170291890-A1 | HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | Epizyme, Inc. | 2017-10-12 | — | — | US | disclosed |
| EP-3194377-A1 | HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044666-A1 | HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016044666-A1 | HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170291890-A1 | HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | HCCS, TP53, NME2 | KDM4C 444/4885KDM5B 1041/4885KDM5A 1394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.