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Sugi Predict / Targets / NME2

NME2

Nucleoside diphosphate kinase B · P22392 · NME2 on Sugi Atlas →

1,062 patent compounds predicted against NME2, 879 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL10852257 SCHEMBL10852257 0.69 7/20
SCHEMBL10853916 SCHEMBL10853916 0.67 6/20
SCHEMBL10856141 SCHEMBL10856141 0.62 6/20
SCHEMBL10854099 SCHEMBL10854099 0.61 6/20
SCHEMBL10857147 SCHEMBL10857147 0.72 5/20
SCHEMBL10854899 SCHEMBL10854899 0.71 5/20
SCHEMBL10856046 SCHEMBL10856046 0.66 5/20
SCHEMBL10857168 SCHEMBL10857168 0.71 4/20
SCHEMBL10858744 SCHEMBL10858744 0.60 4/20
SCHEMBL11085206 SCHEMBL11085206 0.54 4/20
SCHEMBL11085210 SCHEMBL11085210 0.54 4/20
SCHEMBL10856824 SCHEMBL10856824 0.53 4/20
SCHEMBL10856870 SCHEMBL10856870 0.53 4/20
SCHEMBL10849851 SCHEMBL10849851 0.49 4/20
SCHEMBL10849882 SCHEMBL10849882 0.49 4/20
SCHEMBL10849926 SCHEMBL10849926 0.49 4/20
SCHEMBL11081584 SCHEMBL11081584 0.46 4/20
SCHEMBL11081588 SCHEMBL11081588 0.46 4/20
SCHEMBL11081466 SCHEMBL11081466 0.46 4/20
SCHEMBL11081469 SCHEMBL11081469 0.46 4/20

Clinical trials — most relevant to NME2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis PHASE4NOT_YET_RECRUITING
Acelarin First Line Randomised Pancreatic Study PHASE2/PHASE3SUSPENDED
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia PHASE2COMPLETED
A Study to Assess APO866 for the Treatment of Advanced Melanoma PHASE2COMPLETED
Precise Neoadjuvant Chemoresection of Low Grade NMIBC PHASE2NOT_YET_RECRUITING
A Phase 1/2 Study of Safety and Tolerability of MT-125 With Chemoradiation in Patients With Newly Diagnosed MGMT Methylated Glioblastoma PHASE1/PHASE2NOT_YET_RECRUITING
Study of Gemcitabine, Carboplatin and VELIPARIB (ABT-888) in Refractory Testicular Germ Cell Cancer PHASE2COMPLETED
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome PHASE1/PHASE2COMPLETED
Clofarabine Plus Cytarabine in Patients With Previously Untreated Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome PHASE2COMPLETED
Combination Chemotherapy, and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer PHASE2COMPLETED
Drug-drug Interactions Between Remdesivir and Commonly Used Antiretroviral Therapy PHASE2COMPLETED
A Study of Sorafenib in Patients With Chemonaive Metastatic Uveal Melanoma PHASE2UNKNOWN
A Phase 1/2 Study of the Safety and Tolerability of MT-125 in GBM Patients PHASE1/PHASE2RECRUITING
Sirtuin-NAD Activator in Alzheimer's Disease PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC PHASE2COMPLETED
Evaluation of Nicotinamide Riboside in Prevention of Small Fiber Axon Degeneration and Promotion of Nerve Regeneration PHASE2COMPLETED
Safety, Tolerance, Pharmacokinetic and Antiviral Study of Amdoxovir in Combination With Zidovudine in Adults With HIV PHASE1/PHASE2COMPLETED
Epirubicin, Docetaxel, and Capecitabine in Treating Women With Stage IIIA or Stage IIIB Breast Cancer PHASE2COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults PHASE1RECRUITING
A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients EARLY_PHASE1RECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression nanCOMPLETED
The Roles of Neutrophil Elastase in Lung Cancer nanUNKNOWN
Genetics of Neonatal Encephalopathy and Related Disorders nanRECRUITING
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
DNA Adductomics for Colorectal Cancer Investigation nanUNKNOWN
Genetic Analysis of Familial Melanoma nanCOMPLETED
Natural History Study for Patients With Nemaline Myopathy in Spain nanRECRUITING
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart nanUNKNOWN
Cyclosporin A Therapy in Childhood Nephrotic Syndrome nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a NME2 binder may also engage these)

ProteinNameSimilarity
Q5RFH3 — 1.000 Q5RFH3 →
Q2EN76 — 1.000 Q2EN76 →
Q01768 — 1.000 Q01768 →
P27950 — 1.000 P27950 →
Q3T0Q4 — 1.000 Q3T0Q4 →
P70010 — 1.000 P70010 →
Q50KA9 — 1.000 Q50KA9 →
Q90380 — 1.000 Q90380 →
Q50KA8 — 1.000 Q50KA8 →
Q3AFJ7 — 1.000 Q3AFJ7 →
Q6XI71 — 1.000 Q6XI71 →
O57535 — 1.000 O57535 →
P52175 — 1.000 P52175 →
P19804 — 1.000 P19804 →
Q05982 — 1.000 Q05982 →
Q0W8X1 — 0.999 Q0W8X1 →
Q5KXU2 — 0.999 Q5KXU2 →
B1WQB7 — 0.999 B1WQB7 →
P15532 — 0.999 P15532 →
B8HUM7 — 0.999 B8HUM7 →
Q116S1 — 0.998 Q116S1 →
P70011 — 0.998 P70011 →
A6N0M9 — 0.997 A6N0M9 →
P08879 — 0.997 P08879 →
Q5RC56 — 0.997 Q5RC56 →
Q56E62 — 0.997 Q56E62 →
P74494 — 0.997 P74494 →
Q73AY0 — 0.996 Q73AY0 →
A2BZG4 — 0.996 A2BZG4 →
B2IX22 — 0.996 B2IX22 →