Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 10/20 | 0.92 |
| ▸ | ATM | Q13315 | 7/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167275 | 0.96 | PRKDC (1.00) | PRKDCATMKCNH2MAP2K1GPR6 | |
| SCHEMBL167830 | 0.87 | PRKDC (0.75) | PRKDCATMKCNH2PDGFRBATR | |
| SCHEMBL10059173 | 0.86 | PRKDC (0.82) | PRKDCATMMAP2K1 | |
| SCHEMBL167978 | 0.85 | PRKDC (0.80) | PRKDCATM | |
| SCHEMBL256582 | 0.82 | PRKDC (0.74) | PRKDCATMKCNH2ATR | |
| SCHEMBL20031059 | 0.81 | PRKDC (0.77) | PRKDCATM | |
| SCHEMBL257198 | 0.79 | PRKDC (0.81) | PRKDCATMKCNH2 | |
| SCHEMBL167419 | 0.79 | PRKDC (0.81) | PRKDCATMKCNH2 | |
| SCHEMBL10059170 | 0.78 | PRKDC (0.73) | PRKDCATMKCNH2 | |
| SCHEMBL166327 | 0.78 | PRKDC (0.72) | PRKDCATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609082-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028233-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |