Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 11/20 | 0.74 |
| ▸ | ATM | Q13315 | 5/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | FLT1 | P17948 | 2/20 | 0.34 |
| ▸ | FLT4 | P35916 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168204 | 0.89 | PRKDC (0.68) | PRKDCATMFGFR1FLT1FLT4 | |
| SCHEMBL10059173 | 0.87 | PRKDC (0.82) | PRKDCATMPIK3CDPIK3CAPIK3CB | |
| SCHEMBL167275 | 0.85 | PRKDC (1.00) | PRKDCATMPIK3CDPIK3CAPIK3CB | |
| SCHEMBL20031059 | 0.84 | PRKDC (0.77) | PRKDCATMFGFR1FLT1FLT4 | |
| SCHEMBL176122 | 0.82 | PRKDC (0.92) | PRKDCATMKCNH2ATR | |
| SCHEMBL10059170 | 0.82 | PRKDC (0.73) | PRKDCATMPIK3CDPIK3CAPIK3CB | |
| SCHEMBL167830 | 0.81 | PRKDC (0.75) | PRKDCATMPIK3CDPIK3CAPIK3CB | |
| SCHEMBL257587 | 0.81 | PRKDC (0.63) | PRKDCATMPIK3CDPIK3CAPIK3CB | |
| SCHEMBL15064295 | 0.80 | PRKDC (0.73) | PRKDCATMFGFR1FLT1FLT4 | |
| SCHEMBL166327 | 0.79 | PRKDC (0.72) | PRKDCATMKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028233-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |