Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.41 |
| ▸ | RET | P07949 | 6/20 | 0.40 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612970 | 0.89 | BRAF (0.38) | BRAFABL1 | |
| SCHEMBL12397291 | 0.87 | ABL1 (0.51) | ABL1BCR | |
| SCHEMBL12397273 | 0.85 | ABL1 (0.49) | BRAFABL1BCR | |
| SCHEMBL17612891 | 0.82 | BRAF (0.42) | BRAFABL1BCR | |
| SCHEMBL12397355 | 0.82 | ABL1 (0.46) | BRAFABL1BCR | |
| SCHEMBL12397347 | 0.82 | ABL1 (0.46) | BRAFABL1BCR | |
| SCHEMBL12397439 | 0.82 | ABL1 (0.55) | ABL1BCR | |
| SCHEMBL12397363 | 0.80 | ABL1 (0.44) | BRAFABL1BCR | |
| SCHEMBL17612914 | 0.80 | DDR2 (0.49) | BRAFRETABL1BCRKIT | |
| SCHEMBL12397372 | 0.79 | ABL1 (0.42) | BRAFABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173734-B1 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2016-03-23 | — | — | EP | disclosed |