Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | CSK | P41240 | 4/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.37 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612864 | 0.87 | BRAF (0.43) | BRAFPOLBACKR3ABL1 | |
| SCHEMBL12397429 | 0.87 | ABL1 (0.48) | BRAFABL1 | |
| SCHEMBL17612997 | 0.85 | DDR2 (0.50) | BRAFKITDDR1ABL1 | |
| SCHEMBL12397024 | 0.83 | ABL1 (0.48) | BRAFABL1 | |
| SCHEMBL12397363 | 0.82 | ABL1 (0.44) | BRAFABL1 | |
| SCHEMBL12397428 | 0.81 | ABL1 (0.46) | BRAFABL1 | |
| SCHEMBL12397437 | 0.80 | ABL1 (0.49) | BRAFABL1 | |
| SCHEMBL12397016 | 0.80 | ABL1 (0.49) | BRAFABL1 | |
| SCHEMBL12397439 | 0.80 | ABL1 (0.55) | ABL1 | |
| SCHEMBL12397431 | 0.79 | ABL1 (0.51) | BRAFABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173734-B1 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2016-03-23 | — | — | EP | disclosed |