Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19998244 | 0.83 | FOLH1 (0.30) | — | |
| SCHEMBL12023038 | 0.82 | TSHR (0.46) | TDP1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL25741042 | 0.82 | — | — | |
| SCHEMBL17599662 | 0.82 | TDP1 (0.32) | TDP1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL10044377 | 0.82 | ALDH1A1 (0.43) | TDP1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5596714 | 0.80 | TDP1 (0.31) | TDP1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL13639135 | 0.80 | ALDH1A1 (0.35) | TDP1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL17613644 | 0.79 | TDP1 (0.33) | TDP1 | |
| SCHEMBL5596366 | 0.78 | TDP1 (0.32) | TDP1 | |
| SCHEMBL17613625 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346883-B1 | SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE | PETERSEN SCOTT G (US) | 2016-03-23 | — | — | EP | disclosed |