Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 5/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585852 | 0.91 | PDE4D (0.43) | PRF1POLQMAOAMAOBPDE4D | |
| SCHEMBL2591371 | 0.87 | PDE4D (0.43) | PRF1POLQPDE4DABCG2IMPDH2 | |
| SCHEMBL2585714 | 0.87 | PRF1 (0.42) | PRF1POLQMAOAMAOBPDE4D | |
| SCHEMBL17613825 | 0.85 | HSD17B1 (0.36) | PDE4DMAPTACHE | |
| SCHEMBL17614022 | 0.83 | PDE4D (0.42) | PRF1POLQMAOAMAOBPDE4D | |
| SCHEMBL2588346 | 0.83 | PRF1 (0.44) | PRF1POLQPDE4DABCG2 | |
| SCHEMBL14737012 | 0.81 | PRF1 (0.46) | PRF1POLQPDE4DABCG2IMPDH2 | |
| SCHEMBL17613873 | 0.80 | PRF1 (0.39) | PRF1POLQMAOAMAOBPDE4D | |
| SCHEMBL2587910 | 0.79 | PDE4D (0.49) | PRF1PDE4DMAPTABCG2IMPDH2 | |
| SCHEMBL2592221 | 0.79 | PDE4D (0.47) | PRF1POLQMAOAMAOBPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | disclosed |