Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588141 | 0.90 | KDM4E (0.47) | ALDH1A1KDM4EHPGDPDE4DMAPT | |
| SCHEMBL2590899 | 0.88 | KDM4E (0.47) | ALDH1A1KDM4EHPGDPDE4DMAPT | |
| SCHEMBL17613866 | 0.86 | ALDH1A1 (0.34) | ALDH1A1KDM4EHPGDGAACHRM3 | |
| SCHEMBL2581410 | 0.81 | KDM4E (0.52) | ALDH1A1KDM4EHPGDGAAPDE4D | |
| SCHEMBL2589181 | 0.79 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDGAAPDE4D | |
| SCHEMBL14738034 | 0.79 | KDM4E (0.43) | ALDH1A1KDM4EHPGDPDE4DMAPT | |
| SCHEMBL17613839 | 0.78 | ABCB1 (0.32) | ALDH1A1GAA | |
| SCHEMBL14737053 | 0.77 | KDM4E (0.44) | ALDH1A1KDM4EHPGDPDE4DMAPT | |
| SCHEMBL2584453 | 0.77 | KDM4E (0.43) | ALDH1A1KDM4EHPGDPDE4DMAPT | |
| SCHEMBL14737092 | 0.77 | KDM4E (0.43) | ALDH1A1KDM4EHPGDPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | disclosed |