Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | PLK4 | O00444 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | ROS1 | P08922 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | FLT4 | P35916 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | FRK | P42685 | 2/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.35 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.35 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.35 |
| ▸ | SRMS | Q9H3Y6 | 2/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591016 | 0.89 | KDR (0.36) | KDRROCK1PLK4ROCK2NTRK1 | |
| SCHEMBL2588770 | 0.87 | KDR (0.36) | KDRROCK1PLK4ROCK2NTRK1 | |
| SCHEMBL17613981 | 0.85 | KDR (0.39) | KDRROCK1PLK4ROCK2NTRK1 | |
| SCHEMBL17614021 | 0.85 | PIK3CD (0.39) | KDRROCK1PLK4ROCK2NTRK1 | |
| SCHEMBL2591886 | 0.84 | KDR (0.38) | KDRROCK1PLK4ROCK2NTRK1 | |
| SCHEMBL17613862 | 0.83 | PIK3CD (0.35) | KDRROCK1PLK4ROCK2NTRK1 | |
| SCHEMBL2589484 | 0.82 | KDR (0.38) | KDRROCK1PLK4ROCK2NTRK1 | |
| SCHEMBL17613865 | 0.82 | ALDH1A1 (0.33) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL14737000 | 0.78 | PIK3CD (0.34) | KDRROCK1PLK4ROCK2NTRK1 | |
| SCHEMBL2591337 | 0.77 | KDR (0.40) | KDRROCK1PLK4ROCK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | disclosed |