Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 11/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | GLA | P06280 | 5/20 | 0.63 |
| ▸ | GAA | P10253 | 5/20 | 0.63 |
| ▸ | HPGD | P15428 | 5/20 | 0.63 |
| ▸ | MAOA | P21397 | 2/20 | 0.63 |
| ▸ | CASP1 | P29466 | 2/20 | 0.63 |
| ▸ | CASP7 | P55210 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17615429 | 1.00 | ERN1 (0.68) | ERN1KDM4EALDH1A1GLAGAA | |
| SCHEMBL17615419 | 0.99 | ERN1 (0.70) | ERN1KDM4EALDH1A1GLAGAA | |
| SCHEMBL17618267 | 0.81 | ERN1 (1.00) | ERN1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3789883 | 0.80 | KDM4E (0.72) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL17601922 | 0.79 | ERN1 (1.00) | ERN1KDM4EALDH1A1GLAGAA | |
| SCHEMBL31454897 | 0.77 | ALDH1A1 (0.63) | ERN1KDM4EALDH1A1GLAGAA | |
| SCHEMBL17601914 | 0.76 | ERN1 (1.00) | ERN1KDM4EALDH1A1GLAGAA | |
| SCHEMBL16198053 | 0.76 | ERN1 (0.86) | ERN1 | |
| SCHEMBL10790707 | 0.76 | KDM4E (0.61) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL17615426 | 0.76 | ERN1 (0.82) | ERN1KDM4EALDH1A1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160083361-A1 | INHIBITORS OF THE IRE-1/XBP-1 PATHWAY AND METHODS OF USING THEREOF | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083361-A1 | INHIBITORS OF THE IRE-1/XBP-1 PATHWAY AND METHODS OF USING THEREOF | XBP1, RRP1B, ERN1 | ERN1 3/4885KDM4E 3704/4885ALDH1A1 2009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.