Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23211184 | 0.80 | KMT2A (0.64) | KMT2ALMNASMN1; SMN2CYP2C9MAPT | |
| SCHEMBL3516690 | 0.80 | KMT2A (0.68) | KMT2ALMNAGSK3AGSK3B | |
| SCHEMBL17622451 | 0.78 | KMT2A (0.49) | KMT2ALMNASMN1; SMN2CYP2C9MAPT | |
| SCHEMBL4160782 | 0.77 | KMT2A (0.64) | KMT2ALMNATDP1GSK3AGSK3B | |
| SCHEMBL17622450 | 0.74 | KMT2A (1.00) | KMT2ALMNASMN1; SMN2CYP2C9MAPT | |
| SCHEMBL23211205 | 0.73 | KMT2A (0.59) | KMT2ALMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL3519506 | 0.70 | KMT2A (0.56) | KMT2ALMNAALDH1A1 | |
| SCHEMBL23249559 | 0.70 | KMT2A (0.51) | KMT2ALMNASMN1; SMN2CYP2C9MAPT | |
| SCHEMBL4170112 | 0.69 | KMT2A (0.53) | KMT2ALMNAMAPTGAAMEN1 | |
| SCHEMBL4162994 | 0.69 | KMT2A (0.53) | KMT2ALMNASMN1; SMN2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236130-B2 | Divalent nucleobase compounds and uses therefor | CARNEGIE MELLON UNIVERSITY (US) | 2022-02-01 | — | — | US | disclosed |
| US-10370415-B2 | Divalent nucleobase compounds and uses therefor | CARNEGIE MELLON UNIVERSITY (US) | 2019-08-06 | — | — | US | disclosed |
| US-20160083434-A1 | DIVALENT NUCLEOBASE COMPOUNDS AND USES THEREFOR | CARNEGIE MELLON UNIVERSITY (US) | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11236130-B2 | Divalent nucleobase compounds and uses therefor | DNTT, PNKP, GNA11 | KMT2A 2570/4885LMNA 1682/4885SMN1; SMN2 2117/4885 |
| US-20160083434-A1 | DIVALENT NUCLEOBASE COMPOUNDS AND USES THEREFOR | DNTT, POLM, POLL | KMT2A 2921/4885LMNA 1929/4885SMN1; SMN2 2424/4885 |
| US-10370415-B2 | Divalent nucleobase compounds and uses therefor | DNTT, POLM, POLL | KMT2A 2921/4885LMNA 1929/4885SMN1; SMN2 2424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.