GNA11

Guanine nucleotide-binding protein subunit alpha-11 · P29992 · GNA11 on Sugi Atlas →

268 patent compounds predicted against GNA11, 153 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL13820269 SCHEMBL13820269 1.00 8/20
SCHEMBL14361129 SCHEMBL14361129 1.00 8/20
SCHEMBL22133450 SCHEMBL22133450 1.00 8/20
SCHEMBL22139627 SCHEMBL22139627 1.00 8/20
SCHEMBL22404881 SCHEMBL22404881 1.00 8/20
SCHEMBL22404883 SCHEMBL22404883 1.00 8/20
SCHEMBL26118416 SCHEMBL26118416 1.00 8/20
SCHEMBL26121610 SCHEMBL26121610 1.00 8/20
SCHEMBL22139625 SCHEMBL22139625 0.93 8/20
SCHEMBL29587750 SCHEMBL29587750 0.93 8/20
SCHEMBL29799481 SCHEMBL29799481 0.92 8/20
SCHEMBL22139591 SCHEMBL22139591 0.90 8/20
SCHEMBL29884447 SCHEMBL29884447 0.90 8/20
SCHEMBL22133305 SCHEMBL22133305 0.90 8/20
SCHEMBL29540174 SCHEMBL29540174 0.90 8/20
SCHEMBL29393036 SCHEMBL29393036 0.89 8/20
SCHEMBL22133449 SCHEMBL22133449 0.87 8/20
SCHEMBL22133467 SCHEMBL22133467 0.87 8/20
SCHEMBL22133302 SCHEMBL22133302 0.86 8/20
SCHEMBL29375264 SCHEMBL29375264 0.86 8/20

Clinical trials — most relevant to GNA11 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Safety and Efficacy of GS-100 Gene Therapy in Patients With NGLY1 Deficiency PHASE3ACTIVE_NOT_RECRUITING
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome PHASE3COMPLETED
R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas PHASE2COMPLETED
PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome PHASE1/PHASE2COMPLETED
Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients PHASE1/PHASE2COMPLETED
ADH1 and ADH2 Disease Monitoring Study (DMS) nanACTIVE_NOT_RECRUITING
GNAO1 Natural History Study nanUNKNOWN
NGLY1 Natural History nanCOMPLETED
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions nanCOMPLETED
Long-read Genome Sequencing for the Molecular Diagnosis of Dystonia nanRECRUITING
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo) nanWITHDRAWN
GNE-Myopathy Disease Monitoring Program (GNEM-DMP): A Registry and Prospective Observational Natural History Study to Assess GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM) nanCOMPLETED
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients nanRECRUITING
Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer nanUNKNOWN
A Natural History Study of Patients With GNE Myopathy and GNE-Related Diseases nanCOMPLETED
Study on the Carcinogenesis of Gα12 in Oral Cancer, and the Treatment of Oral Cancer Using Ga12 Inhibitor. nanUNKNOWN
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Clinical, Genetic, and Epidemiologic Study of Children and Adults With RASopathies nanRECRUITING
Histamine Responsiveness in McCune-Albright Syndrome nanCOMPLETED
An Investigation of Small Intestinal Carcinoid Carcinoma in Families nanUNKNOWN
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic nanCOMPLETED
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles nanACTIVE_NOT_RECRUITING
Modifying Genes in Neurofibromatosis 1 nanUNKNOWN
Clinical Genetics Branch Eligibility Screening Survey nanNOT_YET_RECRUITING
Genetics and Psychopathology in the 22q11 Deletion Syndrome nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a GNA11 binder may also engage these)

ProteinNameSimilarity
P38409 1.000 P38409 →
Q2XSV9 1.000 Q2XSV9 →
P45645 1.000 P45645 →
Q2PKF4 1.000 Q2PKF4 →
P21278 1.000 P21278 →
P38410 1.000 P38410 →
P38408 1.000 P38408 →
P43444 1.000 P43444 →
P82471 1.000 P82471 →
Q9JID2 1.000 Q9JID2 →
P30677 1.000 P30677 →
Q28294 1.000 Q28294 →
P38411 1.000 P38411 →
O95837 1.000 O95837 →
P91950 1.000 P91950 →
O15975 1.000 O15975 →
O73819 1.000 O73819 →
P21279 1.000 P21279 →
Q9BIG5 1.000 Q9BIG5 →
P38412 1.000 P38412 →
P23625 1.000 P23625 →
Q61B55 1.000 Q61B55 →
P19086 1.000 P19086 →
GNAQ Guanine nucleotide-binding protein G(q) subunit alpha 1.000 landscape →
O70443 0.999 O70443 →
P20612 0.999 P20612 →
Q9XZV3 0.999 Q9XZV3 →
Q61DE0 0.998 Q61DE0 →
P04695 0.998 P04695 →
P0C7Q4 0.998 P0C7Q4 →