Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 2/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.50 |
| ▸ | BMP4 | P12644 | 1/20 | 0.50 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2971282 | 0.82 | BMP4 (0.57) | JAK1PIK3C3BMP4SMPD3AXL | |
| SCHEMBL29799087 | 0.79 | KDR (0.61) | JAK1PIK3C3BMP4SMPD3AXL | |
| SCHEMBL28133532 | 0.78 | DYRK1A (0.58) | JAK1PIK3C3BMP4KDR | |
| Hydrochloric Acid SCHEMBL29504907 | 0.78 | KDR (0.59) | JAK1PIK3C3BMP4SMPD3AXL | |
| SCHEMBL1762156 | 0.76 | SMPD3 (0.45) | JAK1PIK3C3BMP4SMPD3AXL | |
| SCHEMBL7112314 | 0.73 | KDR (0.59) | JAK1PIK3C3BMP4SMPD3AXL | |
| SCHEMBL1761793 | 0.73 | SMPD3 (0.53) | JAK1PIK3C3BMP4SMPD3AXL | |
| SCHEMBL376785 | 0.73 | JAK1 (0.48) | JAK1PIK3C3BMP4SMPD3AXL | |
| SCHEMBL28885304 | 0.73 | SMPD3 (0.53) | JAK1PIK3C3BMP4SMPD3AXL | |
| SCHEMBL5316717 | 0.73 | JAK1 (0.48) | JAK1PIK3C3BMP4SMPD3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937064-B2 | Pyrazolo[1,5-a]pyrimidines useful as JAK2 inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-01-20 | — | — | US | disclosed |
| US-20110118255-A1 | PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JAK2 INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-05-19 | — | — | US | disclosed |
| EP-2252618-A1 | PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009085913-A1 | PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118255-A1 | PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JAK2 INHIBITORS | JAK2, JAK1, JAK3 | JAK1 2/4885PIK3C3 25/4885BMP4 3507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.