Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 12/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 2/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20556089 | 0.88 | IDH1 (0.53) | IDH1HRH4CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL19386336 | 0.85 | HRH4 (0.52) | IDH1HRH4CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL17601231 | 0.83 | HRH4 (0.50) | IDH1HRH4CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL17601503 | 0.83 | HRH4 (0.50) | IDH1HRH4CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL30064815 | 0.83 | HRH4 (0.50) | IDH1HRH4CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL17601234 | 0.83 | HRH4 (0.50) | IDH1HRH4CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL30065517 | 0.83 | HRH4 (0.50) | IDH1HRH4CYP1A2CYP2C19SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL30612982 | 0.82 | HRH4 (0.49) | IDH1HRH4CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL20559203 | 0.76 | IDH1 (0.49) | IDH1HRH4CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL20559199 | 0.76 | IDH1 (0.49) | IDH1HRH4CYP1A2CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016044787-A1 | PYRIDINYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-03-24 | — | — | WO | disclosed |