Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 2/20 | 0.33 |
| ▸ | FPR2 | P25090 | 2/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17626350 | 0.94 | KCNH2 (0.52) | KCNH2MC4RP2RX7FPR1FPR2 | |
| SCHEMBL15750653 | 0.92 | KCNH2 (0.55) | KCNH2FPR1FPR2KMT2A | |
| SCHEMBL2068274 | 0.92 | KCNH2 (0.48) | KCNH2MC4R | |
| SCHEMBL1047347 | 0.91 | KCNH2 (0.52) | KCNH2P2RX7KDM4EMAPTCSNK1E | |
| SCHEMBL17626365 | 0.88 | KCNH2 (0.56) | KCNH2P2RX7FPR1FPR2CSNK1E | |
| SCHEMBL15750810 | 0.88 | KCNH2 (0.52) | KCNH2P2RX7KDM4EMAPTCSNK1E | |
| SCHEMBL20121541 | 0.87 | KCNH2 (0.57) | KCNH2P2RX7KDM4EMAPTCSNK1E | |
| SCHEMBL17626378 | 0.86 | KCNH2 (0.52) | KCNH2P2RX7FPR1FPR2MAPT | |
| SCHEMBL17626374 | 0.86 | KCNH2 (0.52) | KCNH2P2RX7FPR1FPR2MAPT | |
| SCHEMBL2069062 | 0.85 | KCNH2 (0.51) | KCNH2MC4RP2RX7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2737927-B1 | Imidazo[1,2a]pyrazines and compositions comprising them for the treatment of parasitic diseases | NOVARTIS AG (CH) | 2016-03-30 | — | — | EP | claimed |
| EP-2737927-B1 | Imidazo[1,2a]pyrazines and compositions comprising them for the treatment of parasitic diseases | NOVARTIS AG (CH) | 2016-03-30 | — | — | EP | disclosed |