Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.52 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 2/20 | 0.32 |
| ▸ | FPR2 | P25090 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17626374 | 1.00 | KCNH2 (0.52) | KCNH2F11P2RX7ITGB3ITGA2B | |
| SCHEMBL15750648 | 0.92 | KCNH2 (0.58) | KCNH2P2RX7ITGB3ITGA2BMEN1 | |
| SCHEMBL15750641 | 0.92 | KCNH2 (0.58) | KCNH2P2RX7ITGB3ITGA2BMEN1 | |
| SCHEMBL2070632 | 0.91 | KCNH2 (0.52) | KCNH2P2RX7 | |
| SCHEMBL17626365 | 0.91 | KCNH2 (0.56) | KCNH2F11P2RX7CSNK1EFPR1 | |
| SCHEMBL17626350 | 0.88 | KCNH2 (0.52) | KCNH2P2RX7CSNK1EKMT2AFPR1 | |
| SCHEMBL17626414 | 0.87 | KCNH2 (0.52) | KCNH2F11P2RX7CSNK1EMEN1 | |
| SCHEMBL17626322 | 0.86 | KCNH2 (0.49) | KCNH2P2RX7CSNK1EMAPTKMT2A | |
| SCHEMBL2068425 | 0.82 | KCNH2 (0.59) | KCNH2P2RX7KMT2A | |
| SCHEMBL17626363 | 0.82 | KCNH2 (0.61) | KCNH2CSNK1EFPR1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2737927-B1 | Imidazo[1,2a]pyrazines and compositions comprising them for the treatment of parasitic diseases | NOVARTIS AG (CH) | 2016-03-30 | — | — | EP | claimed |