Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.45 |
| ▸ | PRKDC | P78527 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17628018 | 0.98 | HRH4 (0.45) | HRH4PRKDCCNR1BTKTSHR | |
| SCHEMBL17628082 | 0.92 | HRH4 (0.51) | HRH4TSHRKMT2ALMNANR4A1 | |
| SCHEMBL17628042 | 0.90 | HRH4 (0.46) | HRH4PRKDCBTKJAK3OPRM1 | |
| SCHEMBL17628039 | 0.90 | HRH4 (0.46) | HRH4PRKDCBTKJAK3OPRM1 | |
| SCHEMBL17628230 | 0.87 | HRH4 (0.46) | HRH4PRKDCBTKTSHRJAK3 | |
| SCHEMBL17628231 | 0.87 | HRH4 (0.46) | HRH4PRKDCBTKTSHRJAK3 | |
| SCHEMBL17628415 | 0.84 | BTK (0.54) | HRH4BTKJAK3 | |
| SCHEMBL17628416 | 0.84 | BTK (0.54) | HRH4BTKJAK3 | |
| SCHEMBL17628467 | 0.84 | HRH4 (0.53) | HRH4OPRM1OPRK1OGFRL1 | |
| SCHEMBL17628466 | 0.84 | HRH4 (0.53) | HRH4OPRM1OPRK1OGFRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170152241-A9 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | YUHAN CORPORATION (KR) | 2017-06-01 | — | — | US | disclosed |
| EP-3006439-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | Yuhan Corporation (KR) | 2016-04-13 | — | — | EP | disclosed |
| US-20160090374-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | YUHAN CORP (KR) | 2016-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152241-A9 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | GPR119, GIPR, P2RY4 | HRH4 4/4885PRKDC 4342/4885CNR1 868/4885 |
| US-20160090374-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | GPR119, GIPR, P2RY4 | HRH4 4/4885PRKDC 4342/4885CNR1 868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.