Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19251687 | 0.85 | PPARG (0.38) | CETPALDH1A1KDM4EPPARGMEN1 | |
| SCHEMBL17629592 | 0.75 | KCNQ2 (0.43) | ALDH1A1KDM4EPPARGMEN1KMT2A | |
| SCHEMBL5646521 | 0.66 | CYP4F2 (0.66) | ALDH1A1KDM4EPPARGMAPT | |
| Hydrochloric Acid SCHEMBL27739628 | 0.65 | CYP4F2 (0.64) | ALDH1A1KDM4EPPARGMAPT | |
| SCHEMBL19251713 | 0.65 | TLR2 (0.39) | CETPALDH1A1KDM4EPPARGMEN1 | |
| SCHEMBL17629595 | 0.65 | EGLN1 (0.54) | ALDH1A1KDM4EMAPT | |
| SCHEMBL19251699 | 0.64 | MAPT (0.39) | CETPALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL17629568 | 0.64 | KDM4E (0.52) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL13581164 | 0.64 | GCGR (0.47) | CETPMAPT | |
| SCHEMBL17629575 | 0.63 | KDM4E (0.44) | ALDH1A1KDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197455-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049097-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | disclosed |