Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17629568 | 0.75 | KDM4E (0.52) | KDM4EALDH1A1TSHRGAAMEN1 | |
| SCHEMBL17629592 | 0.74 | KCNQ2 (0.43) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL17629580 | 0.74 | KDM4E (0.51) | KDM4EALDH1A1TSHRGAAMEN1 | |
| SCHEMBL22838637 | 0.63 | KDM4E (0.43) | KDM4EALDH1A1TSHRGAAMEN1 | |
| SCHEMBL9548196 | 0.62 | KDM4E (0.72) | KDM4EALDH1A1TSHRGAAMEN1 | |
| SCHEMBL23910261 | 0.62 | KDM4E (0.44) | KDM4EALDH1A1MEN1KMT2AALOX15 | |
| SCHEMBL11397372 | 0.62 | TSHR (0.61) | KDM4EALDH1A1TSHRGAAMEN1 | |
| SCHEMBL6190090 | 0.61 | MEN1 (0.44) | KDM4EMEN1KMT2AMAPT | |
| SCHEMBL4464939 | 0.61 | GAA (0.59) | ALDH1A1GAAKMT2AMAPTTOP2A | |
| SCHEMBL13295973 | 0.61 | KDM4E (0.58) | KDM4EALDH1A1TSHRGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197455-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049097-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | disclosed |