Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 13/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 8/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | TSPO | P30536 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17672564 | 0.91 | FFAR1 (0.46) | FFAR1FFAR4KMOMMP2 | |
| SCHEMBL17629927 | 0.86 | FFAR1 (0.38) | FFAR1FFAR4KMOPLA2G10PLA2G2A | |
| SCHEMBL17679977 | 0.83 | FFAR1 (0.36) | FFAR1FFAR4KMOMMP2 | |
| SCHEMBL17629987 | 0.82 | CYP11B1 (0.44) | FFAR1FFAR4 | |
| SCHEMBL28549814 | 0.81 | FFAR1 (0.51) | FFAR1FFAR4KMOMMP2NPSR1 | |
| SCHEMBL5779417 | 0.80 | SETDB1 (0.42) | FFAR1FFAR4 | |
| SCHEMBL17672822 | 0.80 | SETDB1 (0.40) | FFAR1FFAR4 | |
| SCHEMBL17629998 | 0.78 | NAMPT (0.42) | FFAR1FFAR4 | |
| SCHEMBL6223413 | 0.77 | FFAR1 (0.72) | FFAR1FFAR4TSPODRD3 | |
| SCHEMBL28675050 | 0.77 | FFAR1 (0.51) | FFAR1FFAR4KMOMMP2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055947-A1 | ALKYNE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016046782-A1 | IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2016-03-31 | — | — | WO | disclosed |