Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17630051 | 0.84 | GAA (0.46) | GAAHTTVCAM1MAPTNPC1 | |
| SCHEMBL17629991 | 0.83 | GAA (0.41) | GAAHTTVCAM1MAPTNPC1 | |
| SCHEMBL17630000 | 0.82 | MEN1 (0.41) | GAAHTTVCAM1GLAALDH1A1 | |
| SCHEMBL17630181 | 0.81 | VCAM1 (0.42) | GAAHTTVCAM1MAPTNPC1 | |
| SCHEMBL17629945 | 0.81 | VCAM1 (0.47) | GAAHTTVCAM1MAPTNPC1 | |
| SCHEMBL17629985 | 0.79 | MAPT (0.43) | GAAHTTVCAM1MAPTNPC1 | |
| SCHEMBL4725911 | 0.73 | VCAM1 (0.42) | GAAHTTVCAM1MAPTNPC1 | |
| SCHEMBL18449675 | 0.73 | MAPT (0.52) | GAAHTTVCAM1MAPTNPC1 | |
| SCHEMBL14988218 | 0.72 | MAPT (0.48) | GAAHTTVCAM1MAPTNPC1 | |
| SCHEMBL30675942 | 0.71 | PDGFRB (0.44) | GAAHTTMAPTNPC1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016046782-A1 | IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2016-03-31 | — | — | WO | disclosed |
| WO-2016046782-A1 | IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2016-03-31 | — | — | WO | disclosed |