Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17633151 | 0.91 | FGFR1 (0.51) | BRD4MAPTFGFR1POLBSMN1; SMN2 | |
| SCHEMBL31292175 | 0.80 | MTNR1A (0.40) | BRD4MTNR1AMTNR1BMAPTPOLB | |
| SCHEMBL29653734 | 0.80 | KDM4E (0.55) | MTNR1AMTNR1BPOLBSMN1; SMN2HSD17B10 | |
| SCHEMBL19464188 | 0.80 | KDM4E (0.55) | MTNR1AMTNR1BPOLBSMN1; SMN2HSD17B10 | |
| SCHEMBL17263019 | 0.80 | KDM4E (0.51) | BRD4MTNR1AMTNR1BMAPTFGFR1 | |
| SCHEMBL24501448 | 0.80 | USP2 (0.40) | BRD4MTNR1AMTNR1BMAPTFGFR1 | |
| SCHEMBL30640065 | 0.80 | USP2 (0.40) | BRD4MTNR1AMTNR1BMAPTFGFR1 | |
| SCHEMBL30309791 | 0.80 | TSHR (0.40) | BRD4MTNR1AMTNR1BMAPTFGFR1 | |
| SCHEMBL25727797 | 0.80 | USP2 (0.40) | BRD4MTNR1AMTNR1BMAPTFGFR1 | |
| SCHEMBL26680112 | 0.80 | TSHR (0.40) | BRD4MTNR1AMTNR1BMAPTFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197451-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049100-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | disclosed |