Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 20/20 | 0.71 |
| ▸ | EGLN2 | Q96KS0 | 17/20 | 0.71 |
| ▸ | EGLN3 | Q9H6Z9 | 17/20 | 0.71 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17633207 | 1.00 | EGLN1 (0.71) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17633277 | 1.00 | EGLN1 (0.71) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17633230 | 0.88 | EGLN1 (0.73) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17633231 | 0.88 | EGLN1 (0.73) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17633411 | 0.88 | EGLN1 (0.65) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL3778675 | 0.83 | EGLN1 (1.00) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17633129 | 0.82 | EGLN1 (0.61) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17629630 | 0.79 | EGLN1 (0.72) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17629653 | 0.79 | EGLN1 (0.72) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL3773677 | 0.78 | EGLN1 (0.79) | EGLN1EGLN2EGLN3CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197451-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | claimed |
| WO-2016049100-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | claimed |